| Identifier | HPI031091 |
| Interaction | HBX <==> p53 |
| Role & State | RS:0000076,promotor; RS:0000002,activity; |
| Interaction Type | IT:0000287,activate; IT:0000068,transcription; IT:0000026,interact; |
| Biological Process | BP:0006915,apoptosis; BP:0010467,gene expression; |
| Biological Function | BF:0003774,motor activity; |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 11891535_4, Transfection with the p53 expression vector repressed the AFP reporter gene expression in all three hepatoma cells, while overexpression of HBX counteracted the p53-induced repression.
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| Reference | 11891535_6, These results suggest that HBX interacts with p53 to up-regulate AFP gene transcription probably by restoration of the p53-mediated repression of the AFP promotor activity.
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| Reference | 19784739_5, For example, HBX was reported to inactivate the early responses to DNA damage via p53-dependent and -independent pathways by interacting with several DNA damage-binding proteins and was also reported to sensitize cells to p53-mediated apoptosis via ataxia-telangiectasia and Rad3-related (ATR)-dependent signaling.
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