| Identifier | HPI038407 |
| Interaction | IFN-alpha <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000316,induce; IT:0000372,treatment; IT:0000114,activation; |
| Biological Process | BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 17099286_8, Single treatment with IFN-alpha subtypes promoted p53 activation only in PLC/PRF/5 cells.
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| Reference | 17099286_9, These results propose that IFN-alpha subtypes induce cells to undergo apoptosis through p53 activation directly and indirectly, in collaboration with 5-FU, further suggesting the presence of distinct signal pathways for IFN-alpha-induced apoptosis.
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