| Identifier | HPI103749 |
| Interaction | p53 <==> p73 |
| Role & State | RS:0000080,suppressor; |
| Interaction Type | IT:0000068,transcription; IT:0000114,activation; IT:0000078,regulation; |
| Biological Process | BP:0032502,development; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 10706549_8, No p73 protein expression was observed by immunohistochemistry in nonmalignant liver tissue or in HCC. p53 inactivation appeared to be associated with up-regulation of p73 expression, suggesting a compensatory role for p73 in this situation.
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| Reference | 11526499_2, However, p53, but not p73 is considered a tumour-suppressor gene.
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| Reference | 16203738_3, Transient co-transfection of p53 family members showed that p53 and transactivating (TA)-p73, but not TA-p63, repress endogenous AFP transcription additively or independently. p53-independent functions of p73 are further supported by delayed, p73-associated compensation of AFP repression during development of the p53-null mouse.
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| Reference | 19711344_4, Endogenous p53, p63 and p73 were upregulated in response to DNA damage by chemotherapeutic drugs.
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