| Identifier | MPI30800 |
| Interaction | TGF-beta <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000114,activation; IT:0000068,transcription; IT:0000078,regulation; |
| Biological Process | BP:0031099,regeneration; BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | SCL:0000001,extracellular; SCL:0000002,intracellular; |
| Detection Method | --- |
| Reference | 8666158_3, It has provided insights into the concerted action of extracellular (HGF/SF, TGF-alpha, EGF, TGF-beta) and intracellular factors (c-myc, c-fos, c-jun, p53, c-met, and others) in liver regeneration.
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| Reference | 9751125_6, Phenobarbital inhibited both TGF-beta and bleomycin-induced apoptosis and the normal regulation of p53, bcl-2, and bax.
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| Reference | 18212064_6, We propose that activation of TGF-beta signaling restores a dynamic interplay between p53 and TGF-beta effectors that cooperate to effectively target mSin3A to tumor marker AFP and reestablish transcription repression.
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