| Identifier | MPI47606 |
| Interaction | p53 <==> Chk1 |
| Role & State | RS:0000080,suppressor; |
| Interaction Type | IT:0000320,downregulate; |
| Biological Process | --- |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 11599922_2, Chk1 phosphorylates tumor suppressor p53 at multiple sites, while p53 has been shown to downregulate Chk1 expression under stress conditions in vitro, suggesting negative feedback between the two checkpoint proteins.
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| Reference | 11599922_5, These data indicate that p53 regulates Chk1 expression in a tissue-specific manner.
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| Reference | 14516774_4, Previous studies found that p53 regulates the Chk2 homologue Chk1 expression both in vitro and in vivo.
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