Detail information of PPI "HPI002235"

InteractionAFB1  <==>  p53
Role & State        ---
Interaction TypeIT:0000260,decline; IT:0000191,decrease;
Biological ProcessBP:0016446,mutation;
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference10624703_2, To determine whether AFB1 may play a role in HCC in the United States, a search for AFB1 adducts and p53 alterations, potentially induced by AFB1, was conducted in the United States in 23 HCC patients with available tissue samples.
Reference16280384_6, Exposure to a range (0.015-15 microM for 30 min) of AFB1 concentrations caused a concentration-dependent decline in p53 expression in B-CMV1A2 cells, and to a lesser extent, in B3A4 cells.
Reference16280384_7, The AFB1-mediated decrease in p53 continued for at least 12 h after 30-min exposures to 1.5 muM AFB(1).
Reference18467159_9, The Arg249Ser mutation, hallmark of exposure to AFB1, represented half of the changes in p53 in Shanghai.
Reference22100608_6, Direct involvement of the p53 protein in response to AFB1 was verified by using siRNA directed against p53.