Detail information of PPI "HPI005767"

InteractionAkt  <==>  p53
Role & State        ---
Interaction TypeIT:0000114,activation; IT:0000076,inhibition;
Biological ProcessBP:0006915,apoptosis;
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference17121917_0, Statins induce mammalian target of rapamycin (mTOR)-mediated inhibition of Akt signaling and sensitize p53-deficient cells to cytostatic drugs.
Reference18506760_8, Celecoxib also inhibited p(473Ser)Akt, raf and p53 expression, and induced apoptosis by release of cytochrome c and activation of caspase 9, 3, and 6, which were more remarkably in HBx positive cells than in control cells.