Detail information of PPI "HPI008850"

InteractionBR931  <==>  p53
Role & State        ---
Interaction TypeIT:0000128,phosphorylation; IT:0000114,activation; IT:0000032,increase;
Biological ProcessBP:0008219,cell death;
Biological Function        ---
Subcelluar LocationSCL:0000014,mitochondria;
Detection Method        ---
Reference15135649_9, These results suggest that BR931 can increase generation of ROS, leading to DNA damage and p53 phosphorylation, which, in turn, induces the activation of Bax, release of cytochrome-c from mitochondria and activation of caspases, culminating in cell death.