Detail information of PPI "HPI071807"

InteractionTGF-alpha  <==>  p53
Role & State        ---
Interaction TypeIT:0000271,express;
Biological ProcessBP:0031099,regeneration;
Biological Function        ---
Subcelluar LocationSCL:0000001,extracellular; SCL:0000002,intracellular;
Detection Method        ---
Reference8666158_3, It has provided insights into the concerted action of extracellular (HGF/SF, TGF-alpha, EGF, TGF-beta) and intracellular factors (c-myc, c-fos, c-jun, p53, c-met, and others) in liver regeneration.
Reference9755233_10, In patients with colorectal liver metastases, referred for liver surgery, a higher TGF-alpha expression is associated with unfavorable tumor characteristics, whereas p53 and absence of EGFr expression is associated with a better survival after partial liver resection.