Detail information of PPI "HPI071976"

InteractionTGF-beta  <==>  p53
Role & State        ---
Interaction TypeIT:0000316,induce; IT:0000114,activation; IT:0000068,transcription;
Biological ProcessBP:0031099,regeneration;
Biological Function        ---
Subcelluar LocationSCL:0000002,intracellular; SCL:0000001,extracellular;
Detection Method        ---
Reference18212064_6, We propose that activation of TGF-beta signaling restores a dynamic interplay between p53 and TGF-beta effectors that cooperate to effectively target mSin3A to tumor marker AFP and reestablish transcription repression.
Reference20583212_15, CONCLUSION: TGF-beta induces p53-independent and p16(Ink4a)-independent, but Nox4-dependent, p21(Cip1)-dependent, p15(Ink4b)-dependent, and ROS-dependent senescence arrest in well-differentiated HCC cells.
Reference8666158_3, It has provided insights into the concerted action of extracellular (HGF/SF, TGF-alpha, EGF, TGF-beta) and intracellular factors (c-myc, c-fos, c-jun, p53, c-met, and others) in liver regeneration.
Reference9721329_3, The cytokines TNF-alpha, IL-1beta, and INF-gamma synergistically activate iNOS expression in the liver, and the human iNOS gene was first cloned from cytokine-stimulated hepatocytes. iNOS expression requires the transcription factor NF-kappaB and is down-regulated by steroids, TGF-beta, the heat shock response, p53, and nitric oxide (NO) itself.