Detail information of PPI "HPI072310"

InteractionTGF-beta1  <==>  p53
Role & StateRS:0000014,deacetylation;
Interaction TypeIT:0000364,acetylation; IT:0000139,dephosphorylation; IT:0000128,phosphorylation; IT:0000114,activation; IT:0000132,methylation; IT:0000316,induce; IT:0000294,stimulate; IT:0000275,mediate;
Biological ProcessBP:0040007,growth;
Biological Function        ---
Subcelluar LocationSCL:0000010,cytosol;
Detection Method        ---
Reference11799106_10, In contrast, TGF-beta1-mediated promotion of fibroblast growth failed to mediate p53 x IkappaBalpha dissociation.
Reference15004518_9, In conclusion, the results demonstrated that TGF-beta1-induced p53 dephosphorylation is associated with caspase-3 activation, and cytosolic translocation of p21(Cip1/Waf1) and p27(Kip1), resulting in decreased expression of Cdks and cyclins.
Reference15657445_4, ChIP assays show that TGF-beta1 stimulates p53, Smad4, P-Smad2 binding, and histone H3K9 deacetylation and methylation, at the SBE/p53RE.