Detail information of PPI "HPI073696"

InteractionTNP-470  <==>  p53
Role & State        ---
Interaction TypeIT:0000114,activation; IT:0000076,inhibition;
Biological Process        ---
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference17196522_10, In conclusion, cell-cycle inhibition by TNP-470 is mediated at least in part by an activation of p21WAF1/CIP1 because of a p53-dependent mechanism, with reduction of the cyclin D-Cdk4 and cyclin E-Cdk 2 expression.