Detail information of PPI "HPI074577"

InteractionTan IIA  <==>  p53
Role & State        ---
Interaction TypeIT:0000092,degradation; IT:0000227,bind; IT:0000128,phosphorylation; IT:0000076,inhibition; IT:0000114,activation;
Biological ProcessBP:0006915,apoptosis;
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference19591811_7, At the low dose range (0.2-4 microM) of Tan IIA exposure, the DNA structure damage results in the inhibition of RNAPII binding to DNA and the initiation of RNAPII phosphorylation, while higher concentrations of Tan IIA (4-20 microM) cause complete phosphorylation and degradation of RNAPII followed by p53 activation and apoptosis.