Detail information of PPI "HPI085876"

Interactionc-myc  <==>  p53
Role & State        ---
Interaction TypeIT:0000191,decrease;
Biological ProcessBP:0006915,apoptosis; BP:0008283,cell proliferation; BP:0031099,regeneration; BP:0016446,mutation;
Biological Function        ---
Subcelluar LocationSCL:0000002,intracellular; SCL:0000001,extracellular;
Detection Method        ---
Reference10449034_5, The increased apoptosis in c-myc hepatocytes was accompanied by increased p53, bax, and bak and decreased bcl-2 protein levels.
Reference10449034_7, Phenobarbital, a potent liver tumor promoter, inhibited apoptosis in c-myc hepatocytes but not in wild-type hepatocytes, decreased p53 and bax, and increased bcl-2 protein levels.
Reference10461064_10, These results suggest that c-myc amplification is an indicator of malignant potential and poor prognosis in hepatocellular carcinoma. c-myc amplification and p53 alteration may be coparticipating events in the progression of these tumors.
Reference8600696_11, Genetic alterations during hepatocarcinogenesis, among many others constitutive expression of c-myc, mutations of p53, or amplification of cyclins, provide insight in the control of liver cell proliferation and their aberrant function in malignancy.
Reference8666158_3, It has provided insights into the concerted action of extracellular (HGF/SF, TGF-alpha, EGF, TGF-beta) and intracellular factors (c-myc, c-fos, c-jun, p53, c-met, and others) in liver regeneration.