Detail information of PPI "HPI086506"

Interactioncaspase-3  <==>  p53
Role & StateRS:0000002,activity;
Interaction TypeIT:0000271,express; IT:0000372,treatment; IT:0000115,cleavage;
Biological ProcessBP:0006915,apoptosis;
Biological Function        ---
Subcelluar Location        ---
Detection MethodDM:0000428,microscopy; DM:0000040,electron microscopy;
Reference17544621_6, HOC1-induced apoptosis in BEC in a dose-dependent fashion increased the activity of caspase-3 and the expression of p53 and p-JNK.
Reference20207116_4, Viability of cultured hepatocytes was assessed using the MTT assay, whereas apoptosis processes were evaluated by the electron microscopy, detection of DNA laddering, determination of caspase-3 activity, and measuring annexin V, p53 and Bcl-2 protein concentration.
Reference21468663_4, In this study, we showed that etoposide treatment activated caspase-8 and caspase-3, leading to cleavages of p53, Bid and PARP, which subsequently induced apoptosis.