Detail information of PPI "HPI088031"

Interactioncyclin-dependent kinase  <==>  p53
Role & StateRS:0000074,inhibitor;
Interaction TypeIT:0000114,activation; IT:0000157,depend; IT:0000077,regulate; IT:0000271,express;
Biological Process        ---
Biological FunctionBF:0003677,DNA binding;
Subcelluar Location        ---
Detection Method        ---
Reference9049201_1, p21(WAF1/CIP1) is a universal cyclin-dependent kinase (cdk) inhibitor, the expression of which is regulated by p53-dependent and p53-independent pathways.
Reference9118908_0, Carcinogenic potential of benzene and toluene when evaluated using cyclin-dependent kinase activation and p53-DNA binding.
Reference9699537_1, The cyclin-dependent kinase inhibitor p21/WAF1 is regulated by p5S3-dependent and p53-independent pathways.