Detail information of PPI "HPI091157"

Interactiongankyrin  <==>  p53
Role & StateRS:0000080,suppressor;
Interaction TypeIT:0000114,activation; IT:0000128,phosphorylation; IT:0000123,ubiquitination;
Biological Process        ---
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference19513507_5, Further, tumor suppressor p53 was overexpressed in two arsenic-resistant cell lines, but the levels of p53 mediators MDM2 and gankyrin, which regulate the ubiquitination of p53, increased simultaneously.
Reference19513507_6, In addition, an increase in the phosphorylation of Rb at Ser795 in the two cell lines might also result from the presence of MDM2 and gankyrin, which suggest that the inactivation of p53 and Rb contribute to drug resistance.