| Identifier | HPI103423 |
| Interaction | p53 <==> CD95 |
| Role & State | --- |
| Interaction Type | IT:0000371,interaction; |
| Biological Process | --- |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 11692157_3, To examine the interaction of p53 and CD95 in tumors we investigated which alterations in p53 can be linked to loss of CD95 expression in European HCC.
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| Reference | 11692157_5, In 10 of 14 tumors with evidence of p53 aberration there was also loss of CD95 expression, compared to 6 of 25 samples with apparent wild-type p53 (P0.01).
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| Reference | 11692157_7, A significant correlation with differentiation status of the tumor was found for the p53 aberration but not for CD95 expression.
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| Reference | 11692157_9, Functional p53 appears to be a major factor for CD95 expression in hepatocytes, the loss of which could contribute to chemoresistance and possibly immune evasion in hepatocellular carcinoma.
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