| Identifier | HPI103433 |
| Interaction | p53 <==> DR5 |
| Role & State | RS:0000067,receptor; |
| Interaction Type | IT:0000271,express; IT:0000077,regulate; |
| Biological Process | BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | SCL:0000014,mitochondria; |
| Detection Method | --- |
| Reference | 20356045_5, Abrogation of p53 expression by p53 small interfering RNA significantly attenuated 6-DG-induced DR5 expression, thus rendering these cells resistant to TRAIL-induced apoptosis.
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| Reference | 20356045_9, Taken together, these data suggested that in addition to the mitochondrial- and Fas receptor-mediated apoptotic pathways involved, ROS-dependent and p53-regulated DR5 expression was also demonstrated to play a pivotal role in the synergistic enhancement of TRAIL-induced apoptosis instigated by 6-DG in Hep G2 cells.
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