| Identifier | HPI103445 |
| Interaction | p53 <==> Fbxw7 |
| Role & State | --- |
| Interaction Type | IT:0000114,activation; IT:0000157,depend; |
| Biological Process | BP:0016446,mutation; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 15592418_7, We propose that p53-dependent loss of Fbxw7 leads to genetic instability by mechanisms that might involve the activation of Aurora-A, providing a rationale for the early occurrence of these mutations in human cancers. |