| Identifier | HPI103451 |
| Interaction | p53 <==> Gal4 |
| Role & State | RS:0000078,repressor; |
| Interaction Type | IT:0000068,transcription; IT:0000271,express; |
| Biological Process | BP:0006260,replication; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 20040911_2, In this study, we describe the generation of the conditionally replicating adenovirus Adp53sensor for the treatment of p53-dysfunctional tumors. p53-selective attenuation of viral replication was achieved by using p53-dependent expression of the transcriptional repressor Gal4-KRAB that was directed against the adenoviral E1A locus. |