Detail information of PPI "HPI103483"

Interactionp53  <==>  Huh6
Role & State        ---
Interaction TypeIT:0000070,association; IT:0000114,activation;
Biological ProcessBP:0006915,apoptotic cell death; BP:0040007,growth; BP:0008219,cell death;
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference17397394_5, In response to the oxidative stress, Huh6 cells underwent apoptotic cell death in association with the nuclear translocation of p53 and the transactivation of its target gene implicated in apoptotic cell death. siRNA-mediated knockdown of the endogenous p53 conferred the resistance of Huh6 cells to oxidative stress.
Reference21480327_8, However, association of MYBL2/LINC silencing with doxorubicin-induced DNA damage caused stronger growth restraint in p53(-/-) Huh7 and Hep3B cells than in p53(+/+) Huh6 and HepG2 cells.