Detail information of PPI "HPI103487"

Interactionp53  <==>  IGF-IR antibody
Role & StateRS:0000067,receptor;
Interaction TypeIT:0000258,prevent;
Biological ProcessBP:0016446,mutation;
Biological Function        ---
Subcelluar LocationSCL:0000002,intracellular;
Detection Method        ---
Reference12782403_1, The aim of the present study was to investigate the intracellular mediators of the third base mutant of codon 249 in p53 gene (p53mt249) mutation that potentiate IGF-II dependent IGF-I receptor (IGF-IR) signaling. p53mt249 enhanced IGF-II dependent IGF-IR signaling in p53 negative Hep3B hepatoma cells which were specifically prevented by IGF-IR antibody, alpha IR3 and lovastin. p53mt249 increased the number of IGF-II binding sites with no change in the affinity of IGF-IR.