Detail information of PPI "HPI103488"

Interactionp53  <==>  IGFBP1
Role & State        ---
Interaction TypeIT:0000114,activation; IT:0000068,transcription; IT:0000271,express; IT:0000227,bind; IT:0000099,formation;
Biological ProcessBP:0040007,growth; BP:0008219,cell death;
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference18056423_2, Here we show that p53 transcriptional activation leads to enhanced expression of hepatic IGFBP1 (insulin-like growth factor-binding protein-1).
Reference18285608_4, It appears that p53-mediated induction of the gene that encodes insulin-like growth factor-binding protein-1 (IGFBP1) attenuates the cell death response in hepatocytes by preventing the formation of a complex between p53 and the proapoptotic protein BAK.