Detail information of PPI "HPI103499"

Interactionp53  <==>  Ki-67
Role & State        ---
Interaction TypeIT:0000130,overexpression; IT:0000078,regulation; IT:0000271,express;
Biological Process        ---
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference10963376_0, Overexpression of MDM2 protein in intrahepatic cholangiocarcinoma: relationship with p53 overexpression, Ki-67 labeling, and clinicopathological features.
Reference11477549_7, Immunohistochemistry showed that the p53 overexpression was significantly related to the proliferative activities as evaluated by Ki-67 immunostaining and to the histological differentiation.
Reference15966214_6, The primary tumor showed diffuse positive p53, and the highest value of Ki-67 labeling index (LI) among them.
Reference9537436_5, We found that the down-regulation of E-cad, alpha-catenin, and beta-catenin expression significantly correlated with tumor high grade, but not with vascular invasion, metastasis, p53 expression, Ki-67 labeling, or c-erbB2 expression, except for beta-catenin, the down-regulation of which was associated with c-erbB2 down-regulation.
Reference9537436_7, There were, however, no significant correlations between these aberrant CD44 expression and tumor grade, metastasis, vascular invasion, p53 expression, Ki-67 labeling, or c-erbB2 expression, with a few exceptions of CD44s and CD44v5.