Detail information of PPI "HPI103501"

Interactionp53  <==>  LSD1
Role & State        ---
Interaction TypeIT:0000189,target; IT:0000068,transcription; IT:0000026,interact;
Biological ProcessBP:0032502,development;
Biological Function        ---
Subcelluar LocationSCL:0000785,chromatin;
Detection Method        ---
Reference18573881_0, p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo.
Reference18573881_2, We found that p53 directly interacts with lysine-specific demethylase 1 (LSD1) to alter chromatin structure and confer developmental repression of the tumor marker alpha-fetoprotein (AFP).