Detail information of PPI "HPI103664"

Interactionp53  <==>  mutant p53
Role & State        ---
Interaction TypeIT:0000271,express;
Biological ProcessBP:0007631,eating;
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference15004724_3, To determine whether two frequently occurring p53 mutants, R248Q and R273C, would increase the drug resistance of liver cancer cells, stable cell lines expressing these specific p53 mutants were established by transfecting the p53-null Hep3B cells with mutant p53 expression vectors, and then treating them with the anticancer drugs doxorubicin and paclitaxel.