Detail information of PPI "HPI103704"

Interactionp53  <==>  p16
Role & State        ---
Interaction Type        ---
Biological ProcessBP:0016446,mutation;
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference12378511_8, We also examined the expression of above genes in the accompanying biliary dysplasia and found out abnormal expression of p53, cyclin D1 or p16 in 7 out of 13 dysplastic lesions.
Reference16882984_2, Much remains to be learned about the pathways involved in the severe hematopoietic phenotype observed in Bmi1 homozygous mutant mice except for the fact that loss of p53 or concomitant loss of p16(Ink4a) and p19(Arf) functions achieves only a partial rescue.
Reference19070423_5, Hepatocellular carcinoma (HCC) cells display inactivating mutations of p53 and epigenetic silencing of p16(INK4a).