Detail information of PPI "HPI103706"

Interactionp53  <==>  p21 (CIP1/WAF1)
Role & State        ---
Interaction TypeIT:0000076,inhibition; IT:0000078,regulation;
Biological ProcessBP:0040007,growth; BP:0016246,RNA interference; BP:0051320,S-phase; BP:0007049,cell cycle; BP:0007050,cell cycle arrest;
Biological Function        ---
Subcelluar Location        ---
Detection MethodDM:0000256,rna interference;
Reference22226916_10, Ku80 overexpression caused S-phase cell cycle arrest and was associated with upregulation of p53 and p21(CIP1/WAF1), and the inhibition of p53 or p21(CIP1/WAF1) expression by RNA interference overcame the growth suppression and S-phase arrest in the Ku80-expressing cells.