Detail information of PPI "HPI103707"

Interactionp53  <==>  p21 (Cip1/Waf1
Role & State        ---
Interaction TypeIT:0000139,dephosphorylation; IT:0000114,activation; IT:0000128,phosphorylation;
Biological ProcessBP:0006915,apoptosis;
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference15004518_0, p53 dephosphorylation and p21(Cip1/Waf1) translocation correlate with caspase-3 activation in TGF-beta1-induced apoptosis of HuH-7 cells.
Reference15004518_6, This was associated with enhanced p53 dephosphorylation and p21(Cip1/Waf1) expression, which coincided with decreased Cdk2, Cdk4, and cyclin E expression, compared with synchronized G1 cells.