Detail information of PPI "HPI103708"

Interactionp53  <==>  p21 (Cip1/Waf1)
Role & State        ---
Interaction TypeIT:0000076,inhibition; IT:0000139,dephosphorylation; IT:0000128,phosphorylation; IT:0000114,activation;
Biological ProcessBP:0006915,apoptosis;
Biological Function        ---
Subcelluar LocationSCL:0000006,cytoplasm; SCL:0000010,cytosol;
Detection Method        ---
Reference15004518_7, In addition, p53 dephosphorylation coincided with caspase-3 activation, and translocation of p21(Cip1/Waf1) and p27(Kip1) into the cytoplasm, all of which were suppressed by caspase inhibition of TGF-beta1-induced apoptosis.
Reference15004518_9, In conclusion, the results demonstrated that TGF-beta1-induced p53 dephosphorylation is associated with caspase-3 activation, and cytosolic translocation of p21(Cip1/Waf1) and p27(Kip1), resulting in decreased expression of Cdks and cyclins.