| Identifier | HPI026991 |
| Interaction | G-Rs4 <==> p53 |
| Role & State | RS:0000002,activity; |
| Interaction Type | IT:0000326,immunoblot; IT:0000078,regulation; IT:0000280,relate; |
| Biological Process | BP:0006917,induction of apoptosis; BP:0006915,apoptosis; |
| Biological Function | BF:0016301,kinase activity; |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 10448308_5, Immunoblot assays showed that G-Rs4 significantly elevated protein levels of p53 and p21WAF1, concurrently with the downregulation of both cyclins E- and A-dependent kinase activities and induction of apoptosis.
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| Reference | 10448308_6, We suggest that G-Rs4 induces apoptosis, the effect of which is closely related to the downregulation of both cyclins E- and A-dependent kinase activity as a consequence of selectively elevating protein levels of p53 and p21WAF1 in SK-HEP-1 cells.
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