| Identifier | MPI20801 |
| Interaction | MDM2 <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000123,ubiquitination; IT:0000092,degradation; |
| Biological Process | --- |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 17363365_0, MDM2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation. |
| Reference | 17545619_2, MDM2 interaction with p53 results in ubiquitination and 26S proteasomal degradation of p53. |