Identifier | MPI21731 |
Interaction | Mdm2 <==> p53 |
Role & State | --- |
Interaction Type | IT:0000123,ubiquitination; IT:0000092,degradation; |
Biological Process | BP:0006915,apoptosis; |
Biological Function | --- |
Subcelluar Location | --- |
Detection Method | --- |
Reference | 17000718_1, Murine double minute 2 (Mdm2) negatively regulates p53 by mediating its ubiquitination and proteosomal degradation, and Mdm2 is recognized as a proto-oncogene.
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Reference | 17000718_7, Hepatic Mdm2 protein levels were increased, and immunohistochemical evaluation of rat liver demonstrated nuclear localization of Mdm2, suggesting an interaction with p53.
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Reference | 17105817_6, Our data show that Mdm2 is required for rescuing erythroid progenitors from p53-mediated apoptosis during primitive erythropoiesis.
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