| Identifier | MPI27632 |
| Interaction | Rb <==> p53 |
| Role & State | RS:0000002,activity; |
| Interaction Type | IT:0000114,activation; IT:0000238,link; |
| Biological Process | BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 11818069_5, Because unrestrained E2F activity in the absence of Rb function contributes to p53-dependent apoptosis in many systems, we wished to identify genes linking deregulated E2F activity to p53 activation and subsequent apoptosis.
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| Reference | 11818069_7, From the analysis of Rb/ARF compound mutants we demonstrate that ARF is not an obligatory link between Rb inactivation and p53-dependent apoptosis.
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