| Identifier | MPI30436 |
| Interaction | TA-p73 <==> p53 |
| Role & State | RS:0000078,repressor; |
| Interaction Type | --- |
| Biological Process | BP:0016446,mutation; |
| Biological Function | --- |
| Subcelluar Location | SCL:0000785,chromatin; |
| Detection Method | DM:0000402,chromatin immunoprecipitation assay; DM:0000019,immunoprecipitation; |
| Reference | 11526499_8, Most TA-p73-expressing hepatocellular carcinoma cells have also lost p53 function either by lack of expression or missense mutations.
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| Reference | 16203738_4, Chromatin immunoprecipitation assays of normal and p53-null mouse liver tissue showed that TA-p73 binds at a previously identified p53 repressor site (-860/-830) within the distal promoter of AFP at a level equivalent to p53 in wild type liver, with increased binding of TA-p73 to chromatin in the absence of p53.
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