Detail information of PPI "MPI47647"

Interactionp53  <==>  NOS2
Role & State        ---
Interaction Type        ---
Biological ProcessBP:0010467,gene expression;
Biological Function        ---
Subcelluar Location        ---
Detection Method        ---
Reference8637893_5, These data are consistent with the hypothesis of a negative feedback loop in which endogenous NO-induced DNA damage results in WT p53 accumulation and provides a novel mechanism by which p53 safeguards against DNA damage through p53-mediated transrepression of NOS2 gene expression, thus reducing the potential for NO-induced DNA damage.