| Identifier | HPI002235 |
| Interaction | AFB1 <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000260,decline; IT:0000191,decrease; |
| Biological Process | BP:0016446,mutation; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 10624703_2, To determine whether AFB1 may play a role in HCC in the United States, a search for AFB1 adducts and p53 alterations, potentially induced by AFB1, was conducted in the United States in 23 HCC patients with available tissue samples.
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| Reference | 16280384_6, Exposure to a range (0.015-15 microM for 30 min) of AFB1 concentrations caused a concentration-dependent decline in p53 expression in B-CMV1A2 cells, and to a lesser extent, in B3A4 cells.
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| Reference | 16280384_7, The AFB1-mediated decrease in p53 continued for at least 12 h after 30-min exposures to 1.5 muM AFB(1).
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| Reference | 18467159_9, The Arg249Ser mutation, hallmark of exposure to AFB1, represented half of the changes in p53 in Shanghai.
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| Reference | 22100608_6, Direct involvement of the p53 protein in response to AFB1 was verified by using siRNA directed against p53.
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