| Identifier | HPI003416 |
| Interaction | AMPK <==> p53 |
| Role & State | RS:0000080,suppressor; |
| Interaction Type | IT:0000078,regulation; IT:0000176,suppress; IT:0000114,activation; |
| Biological Process | BP:0019538,protein metabolism; BP:0008152,metabolism; BP:0040007,growth; BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 19662644_9, Interestingly, the decision between apoptosis and growth arrest following AMPK activation is greatly influenced by p53 status.
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| Reference | 21538580_2, Although AMPK is traditionally thought to play a major role in the regulation of cellular lipid and protein metabolism, recent discoveries reveal that AMPK inhibits mammalian target of rapamycin (mTOR) signaling and connects with several tumor suppressors such as liver kinase B1 (LKB1), p53, and tuberous sclerosis complex 2 (TSC2), indicating that AMPK may be a potential target for cancer prevention and treatment.
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