| Identifier | HPI008850 |
| Interaction | BR931 <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000128,phosphorylation; IT:0000114,activation; IT:0000032,increase; |
| Biological Process | BP:0008219,cell death; |
| Biological Function | --- |
| Subcelluar Location | SCL:0000014,mitochondria; |
| Detection Method | --- |
| Reference | 15135649_9, These results suggest that BR931 can increase generation of ROS, leading to DNA damage and p53 phosphorylation, which, in turn, induces the activation of Bax, release of cytochrome-c from mitochondria and activation of caspases, culminating in cell death. |