| Identifier | HPI014070 |
| Interaction | COX-2 <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000128,phosphorylation; IT:0000168,inhibit; IT:0000114,activation; IT:0000275,mediate; IT:0000076,inhibition; IT:0000271,express; |
| Biological Process | BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 16800815_5, COX-2 expression blocked these events, concomitant with reduced expression of p53 and promotion of Akt phosphorylation, the latter indicating activation of survival pathways.
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| Reference | 18601905_0, COX-2 mediates hepatitis B virus X protein abrogation of p53-induced apoptosis.
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| Reference | 18601905_3, Using an engineered hepatoma cell system in which the expression of wild-type p53 can be chemically modulated, we show here that COX-2 mediates HBx actions in opposing p53.
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| Reference | 18601905_6, The abrogation of apoptosis is completely reversed by specific COX-2 inhibition, suggesting that HBx blocks p53-induced apoptosis via activation of COX-2/PGE(2) pathway.
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