| Identifier | HPI028241 |
| Interaction | GLS2 <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000271,express; IT:0000357,response; |
| Biological Process | BP:0008219,cell death; |
| Biological Function | --- |
| Subcelluar Location | SCL:0000002,intracellular; |
| Detection Method | --- |
| Reference | 20351271_2, GLS2 expression is induced in response to DNA damage or oxidative stress in a p53-dependent manner, and p53 associates with the GLS2 promoter.
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| Reference | 20351271_5, High ROS levels following GLS2 knockdown also coincide with stimulation of p53-induced cell death.
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| Reference | 20351271_6, We propose that GLS2 control of intracellular ROS levels and the apoptotic response facilitates the ability of p53 to protect cells from accumulation of genomic damage and allows cells to survive after mild and repairable genotoxic stress.
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