| Identifier | HPI029054 |
| Interaction | GSN <==> p53 |
| Role & State | RS:0000002,activity; |
| Interaction Type | IT:0000227,bind; IT:0000076,inhibition; IT:0000057,anchor; IT:0000077,regulate; IT:0000068,transcription; |
| Biological Process | BP:0006915,apoptosis; |
| Biological Function | BF:0016563,transcriptional activity; |
| Subcelluar Location | SCL:0000006,cytoplasm; |
| Detection Method | --- |
| Reference | 21801713_4, Additionally, we demonstrate that GSN negatively regulates p53-dependent transcriptional activity of a reporter construct, driven by the p21-promoter.
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| Reference | 21801713_6, Taken together, these results suggest that GSN binds to p53 and this interaction leads to the inhibition of p53-induced apoptosis by anchoring of p53 in the cytoplasm in HepG2 cells.
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