| Identifier | HPI031813 |
| Interaction | HBxAg <==> p53 |
| Role & State | RS:0000080,suppressor; RS:0000077,regulator; |
| Interaction Type | IT:0000328,immunoprecipitate; IT:0000227,bind; |
| Biological Process | BP:0040007,growth; BP:0032502,development; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | DM:0000019,immunoprecipitation; |
| Reference | 8386823_2, The results showed that anti-p53 specifically immunoprecipitates HBxAg only in the presence of p53 and that anti-x specifically immunoprecipitates p53 only in the presence of HBxAg. to determine whether HBxAg binds p53 in vivo, immunoprecipitation and Western blot analysis of liver samples from 10 hepatitis B virus (HBV)-infected patients with primary hepatocellular carcinoma (PHC) were carried out.
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| Reference | 8386823_5, These findings suggest that HBxAg binds to p53 and that this association is important to the development of PHC.
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| Reference | 9012469_5, HBxAg was detectable in tumor and/or nontumor cells from all patients by IHC; six of these samples also had detectable p53.
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| Reference | 9094970_5, The finding that HBxAg binds to and inactivates negative growth-regulatory molecules, such as the tumor suppressor p53, suggests additional ways that HBxAg may act in hepatocarcinogenesis.
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