| Identifier | HPI035063 |
| Interaction | HSCO <==> p53 |
| Role & State | RS:0000002,activity; |
| Interaction Type | IT:0000168,inhibit; IT:0000130,overexpression; |
| Biological Process | BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 12398897_5, Like I kappa B alpha, HSCO inhibited NF-kappa B activity and abrogated p53-induced apoptosis.
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| Reference | 12398897_8, These results suggest that overexpression of HSCO suppresses p53-induced apoptosis by preventing nuclear localization of NF-kappa B during signaling and thus contributes to hepatocarcinogenesis.
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