| Identifier | HPI035221 |
| Interaction | HSP70 <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000280,relate; IT:0000080,effect; |
| Biological Process | BP:0007049,cell cycle; BP:0007050,cell cycle arrest; BP:0006954,inflammatory response; BP:0006915,apoptosis; BP:0040007,growth; |
| Biological Function | --- |
| Subcelluar Location | SCL:0000002,intracellular; |
| Detection Method | --- |
| Reference | 10420846_10, Based on these results, we propose that the antiapoptotic effect of thermal stress is mediated by increasing HSP70 and modulating intracellular p53 function.
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| Reference | 16224158_4, We examined the expressions of HSP70 and HSP27 by immunohistochemical staining in 71 cases of HCC, and then related their expressions to clinicopathologic parameters and expressions of p53, Ki-67 and Apotag.
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| Reference | 16823072_11, Western Blot analysis demonstrated the potential of PCP to induce oxidative stress and inflammatory response (c-fos), growth arrest and DNA damage (GADD153), proteotoxic effects (HSP70), cell cycle arrest as consequence of DNA damage (p53), mitogenic response (cyclin- D1), and apoptosis (caspase-3).
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