| Identifier | HPI051037 |
| Interaction | MTA1 <==> p53 |
| Role & State | RS:0000014,deacetylation; RS:0000002,activity; |
| Interaction Type | IT:0000364,acetylation; IT:0000145,attenuate; IT:0000271,express; IT:0000025,associate; IT:0000168,inhibit; IT:0000114,activation; |
| Biological Process | BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | DM:0000019,immunoprecipitation; DM:0000019,co-immunoprecipitation; |
| Reference | 17914590_2, We characterized the functional consequences of MTA1 overexpression on p53-induced apoptosis of cancer cells.
|
| Reference | 17914590_3, MTA1 was associated with p53 in a co-immunoprecipitation assay.
|
| Reference | 17914590_4, MTA1 also had deacetylation activity on p53 in human non-small cell lung cancer cells H1299 and human hepatoma cells SK-Hep1.
|
| Reference | 17914590_5, MTA1 attenuated the transactivation and p21 induction by p53.
|
| Reference | 17914590_6, Moreover, MTA1 expression decreased p53-mediated apoptosis.
|
| Reference | 17914590_7, These results indicate that MTA1 inhibits p53-induced apoptosis by deacetylation of p53, which might be related to the increased metastatic potential of cancer cells with high MTA1 expression.
|
| |
|