| Identifier | HPI058581 |
| Interaction | PFT-alpha <==> p53 |
| Role & State | RS:0000074,inhibitor; |
| Interaction Type | IT:0000068,transcription; IT:0000168,inhibit; IT:0000114,activation; |
| Biological Process | BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 17487067_11, PFT-alpha inhibited the transactivation of p53 in rat liver cells and resulted in repression of Bcl2, PCNA, MDM2, Cyclin G and P21 genes by arsenic trioxide.
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| Reference | 17487067_4, Pifithrin-alpha (PFT-alpha) is a reversible inhibitor of p53-mediated apoptosis, p53-dependent gene transcription, as well as down stream responsive gene function.
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