| Identifier | HPI064445 |
| Interaction | ROS <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000077,regulate; IT:0000128,phosphorylation; IT:0000114,activation; |
| Biological Process | BP:0008219,cell death; BP:0006915,apoptosis; |
| Biological Function | --- |
| Subcelluar Location | SCL:0000014,mitochondria; |
| Detection Method | --- |
| Reference | 15135649_9, These results suggest that BR931 can increase generation of ROS, leading to DNA damage and p53 phosphorylation, which, in turn, induces the activation of Bax, release of cytochrome-c from mitochondria and activation of caspases, culminating in cell death.
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| Reference | 17136495_0, Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells.
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| Reference | 22245848_9, Our data demonstrated that silica nanoparticles induced apoptosis in human liver cells, which is ROS mediated and regulated through p53, bax/bcl-2 and caspase pathways.
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