| Identifier | HPI070334 |
| Interaction | Sp1 <==> p53 |
| Role & State | --- |
| Interaction Type | IT:0000026,interact; IT:0000023,complex; IT:0000068,transcription; |
| Biological Process | --- |
| Biological Function | BF:0003677,DNA binding; |
| Subcelluar Location | --- |
| Detection Method | --- |
| Reference | 11384995_3, In transfection experiments, p53 transactivated the p21 promoter in HaCaT cells that express Sp1 but have a mutated p53 form.
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| Reference | 11384995_9, By using deletion mutants we found that the DNA binding domain of Sp1 is required for its physical interaction with p53.
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| Reference | 18948152_3, HBx recruited HDAC1 forms complex with Sp1 in a p53-independent manner) and deacetylates Sp1 which resulted in the diminished binding of Sp1 on targeted DNA during transcriptional repression.
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